Multiple melanoma, prognostic markers and cell senescence


Cell senescence is a permanent state of cell arrest following excessive cell division or oncogene activation, now recognized as a major tumour-suppresor mechanism. Malignant melanoma, the cancer of melanocytes, is the sixth commonest cancer in the UK, and a deadly disease still increasing in incidence.


  • To test whether defective cell senescence is a common factor in multiple melanoma.
  • To study clinical features and novel senescence markers in naevi (moles) and melanomas from these patients, to seek clues to predicting multiple melanoma beforehand, and also prognosis: predicting whether melanoma will recur or spread, and patien survival.
  • To test for links with patients’ attributes like hair colour and gene variants.

From 1 october 2012 for 3 years.



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